Family Nurse Practitioner Exam

Which medication is most likely to cause sexual dysfunction in males?

1. SSRIs

2. ACE inhibitors

3. Amphetamines

4. Atypical antidepressants

The correct answer is: SSRIs

Selective Serotonin Reuptake Inhibitors (SSRIs) are well-known for their potential side effects, one of which is sexual dysfunction in males. This happens because SSRIs increase serotonin levels in the brain, which can inhibit sexual arousal and performance. Commonly reported issues include delayed ejaculation, anorgasmia, and decreased libido. While other medications listed can have side effects, they do not typically create the same likelihood or prevalence of sexual dysfunction. For example, ACE inhibitors may have other side effects, but sexual dysfunction is not a common one. Amphetamines might enhance libido in some cases due to their stimulant properties, though they can lead to issues with sexual performance in the long term. Atypical antidepressants, such as bupropion, are often noted for having a lower risk of sexual side effects compared to SSRIs. Thus, SSRIs are the most recognized in clinical practice for causing sexual dysfunction in males.