Family Nurse Practitioner Exam

Which medication is least likely to cause gastrointestinal distress in a patient with a sensitive stomach?

1. A) Naproxen sodium (Anaprox)

2. B) Aspirin (Bayer's aspirin)

3. C) Erythromycin (E-mycin)

4. D) Sucralfate (Carafate)

The correct answer is: D) Sucralfate (Carafate)

Sucralfate (Carafate) is the medication least likely to cause gastrointestinal distress in a patient with a sensitive stomach because it works primarily by forming a protective barrier over the lining of the stomach and the duodenum. This action helps to shield the mucosal surface from the acidic environment, thus preventing irritation and promoting healing of ulcers. Sucralfate does not have significant systemic absorption and is specifically designed to protect and repair gastrointestinal mucosa rather than irritate it. In contrast, the other options listed can lead to gastrointestinal issues. Naproxen, a nonsteroidal anti-inflammatory drug (NSAID), can irritate the stomach lining, potentially causing gastritis or ulcers due to its inhibition of prostaglandin synthesis, which is important for maintaining the protective mucosal layer. Aspirin, also an NSAID, shares similar risks as naproxen regarding gastrointestinal irritation and bleeding. Erythromycin, an antibiotic, can often cause gastrointestinal discomfort, including nausea and diarrhea, as a result of its effects on gastric motility and its impact on gut flora. Thus, while the other medications can exacerbate gastrointestinal sensitivity, sucralfate is specifically formulated to minimize such distress, making it the most appropriate choice for patients with