Family Nurse Practitioner Exam

Which effect is commonly observed in women using Depo-Provera for over 5 years?

1. Melasma

2. Amenorrhea

3. Weight loss

4. Headaches

The correct answer is: Amenorrhea

Depo-Provera, a form of contraceptive injection that contains medroxyprogesterone acetate, is known to suppress ovulation and lead to changes in the menstrual cycle. Over extended use, particularly beyond five years, one of the most commonly observed effects is amenorrhea, which is the absence of menstruation. This occurs because the hormone levels provided by the injection can cause the endometrial lining to thin, reducing or eliminating menstrual bleeding. This effect is significant for clinicians and patients to consider, as it may indicate effective contraceptive management or potential underlying health concerns. Recognition of amenorrhea as a side effect is crucial for informing patients about what to expect when using Depo-Provera for long durations. While other effects such as melasma, weight gain, and headaches may occur, they might not be as consistently associated with long-term use of this contraceptive. This contributes to amenorrhea being the most prominent effect observed after extended use of Depo-Provera. Understanding this can help in monitoring and managing any side effects while providing patient education regarding the potential outcomes of prolonged use.